Acute Kidney Injury (AKI) is common, expensive to treat, and associated with high mortality [1-4]. Within the field of cardiac surgery, a staggering 30% of patients develop AKI, with significant negative outcomes [1-5]. In the most severe cases, AKI can progress to overt renal failure and dialysis; however, even mild AKI sharply increases the risk of 30-day mortality and long-term progression to chronic kidney disease (CKD) . Although recent research on renal biomarkers has shown promise in diagnosing AKI progression, no tests or models are currently available to effectively identify patients at risk for AKI initiation. If these at-risk patients could be accurately identified prior to surgery, preoperative and perioperative procedures could be modified to minimize the risk of AKI. Such risk minimization is particularly important since there are no pharmacologic therapies available for the effective prevention or treatment of AKI.
Utilizing our proprietary molecular age-based technology, HealthSpan Dx has developed AKI-Sapere, a multivariate molecular assay that can prognostically, prior to coronary artery bypass graft (CABG) surgery, successfully stratify patients for risk of AKI initiation. AKI-Sapere discovery and clinical utility data will be presented at the AKI & CRRT 2018 conference as a selected short talk and a poster.
If you are interested in learning more, contact us.
- Liangos, O. et al. Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 1, 43-51 (2006).
- Palevsky, P.M. Epidemiology of acute renal failure: the tip of the iceberg. Clin J Am Soc Nephrol 1, 6-7 (2006).
- Uchino, S. et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294, 813-818 (2005).
- Lameire, N., Van Biesen, W. & Vanholder, R. Acute renal failure. Lancet 365, 417-430 (2005).
- Dasta, J.F., Kane-Gill, S.L., Durtschi, A.J., Pathak, D.S. & Kellum, J.A. Costs and outcomes of acute kidney injury (AKI) following cardiac surgery. Nephrol Dial Transplant 23, 1970-1974 (2008).
- Chawla, L.S., Amdur, R.L., Amodeo, S., Kimmel, P.L. & Palant, C.E. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney International 79, 1361-1369 (2011).